تداخل‌های دارویی
Etoricoxib + Venlafaxine
شدت: متوسط
Etoricoxib and Venlafaxine: moderate interaction.
آخرین به‌روزرسانی منابع: US FDA label
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Venlafaxine and NSAIDs including selective COX-2 inhibitors such as etoricoxib each increase the risk of bleeding, and together the risk of gastrointestinal and other haemorrhage is higher. The absolute risk is modest in healthy patients but meaningful in older adults and those with prior ulcers. Etoricoxib may carry less gastric toxicity than non-selective NSAIDs but does not remove this risk.
معنای این تداخل به زبان ساده
Etoricoxib and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etoricoxib belongs to Musculoskeletal; Venlafaxine belongs to Central Nervous System.
چرا رخ می‌دهد
Venlafaxine inhibits serotonin reuptake into platelets, depleting platelet serotonin and impairing aggregation, while NSAIDs add mucosal injury and effects on haemostasis. Etoricoxib may also raise blood pressure, which venlafaxine can also do.
اقدام لازم
Use the lowest effective etoricoxib dose for the shortest duration, and consider a PPI in patients with risk factors for GI bleeding. Monitor for bruising, melaena, haematemesis and check blood count if use is prolonged.
از داروساز چه بپرسید
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Etoricoxib و Venlafaxine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
منابع
- Effexor XR (venlafaxine) Prescribing Information - Warnings and Precautions: Abnormal Bleeding — FDA Label
- Arcoxia (etoricoxib) Summary of Product Characteristics — EMA SmPC
تداخلات دیگر Venlafaxine
- Isocarboxazid + Venlafaxine منع مصرف
- Methylene blue + Venlafaxine منع مصرف
- Phenelzine + Venlafaxine منع مصرف
- Procarbazine + Venlafaxine منع مصرف
- Rasagiline + Venlafaxine منع مصرف
- Safinamide + Venlafaxine منع مصرف
پرسش‌های متداول
Can I take Etoricoxib with Venlafaxine?
MediHelp rates the interaction as moderate. Etoricoxib and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venlafaxine and NSAIDs including selective COX-2 inhibitors such as etoricoxib each increase the risk of bleeding, and together the risk of gastrointestinal and other haemorrhage is higher. The absolute risk is modest in healthy patients but meaningful in older adults and those with prior ulcers. Etoricoxib may carry less gastric toxicity than non-selective NSAIDs but does not remove this risk.
How serious is the interaction between Etoricoxib and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective etoricoxib dose for the shortest duration, and consider a PPI in patients with risk factors for GI bleeding. Monitor for bruising, melaena, haematemesis and check blood count if use is prolonged.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
