تداخل‌های دارویی
Fluvoxamine + Phenelzine
شدت: منع مصرف
Fluvoxamine and Phenelzine: contraindicated interaction.
آخرین به‌روزرسانی
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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Phenelzine irreversibly inhibits monoamine oxidase, so serotonin is not broken down, and fluvoxamine is an SSRI that increases synaptic serotonin. Together they can precipitate serotonin syndrome with hyperthermia, agitation, clonus and autonomic instability, which can be fatal.
معنای این تداخل به زبان ساده
Fluvoxamine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fluvoxamine belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
چرا رخ می‌دهد
Excess serotonergic activity (MAO inhibition plus serotonin reuptake or receptor effects)
اقدام لازم
Do not co-administer. Leave at least 14 days after stopping phenelzine before starting fluvoxamine, and at least 14 days after stopping fluvoxamine before starting phenelzine.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Fluvoxamine و Phenelzine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Fluvoxamine
- Agomelatine + Fluvoxamine منع مصرف
- Alosetron + Fluvoxamine منع مصرف
- Fezolinetant + Fluvoxamine منع مصرف
- Fluvoxamine + Isocarboxazid منع مصرف
- Fluvoxamine + Mavacamten منع مصرف
- Fluvoxamine + Methylene blue منع مصرف
تداخلات دیگر Phenelzine
- 5-HTP + Phenelzine منع مصرف
- Amitriptyline + Phenelzine منع مصرف
- Amoxapine + Phenelzine منع مصرف
- Atomoxetine + Phenelzine منع مصرف
- Benzphetamine + Phenelzine منع مصرف
- Brimonidine + Phenelzine منع مصرف
پرسش‌های متداول
Can I take Fluvoxamine with Phenelzine?
MediHelp rates the interaction as contraindicated. Fluvoxamine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenelzine irreversibly inhibits monoamine oxidase, so serotonin is not broken down, and fluvoxamine is an SSRI that increases synaptic serotonin. Together they can precipitate serotonin syndrome with hyperthermia, agitation, clonus and autonomic instability, which can be fatal.
How serious is the interaction between Fluvoxamine and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Leave at least 14 days after stopping phenelzine before starting fluvoxamine, and at least 14 days after stopping fluvoxamine before starting phenelzine.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
