تداخل‌های دارویی
Fezolinetant + Fluvoxamine
شدت: منع مصرف
Fezolinetant and Fluvoxamine: contraindicated interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Fezolinetant is metabolised mainly by CYP1A2, and fluvoxamine is a strong CYP1A2 inhibitor that greatly increases its exposure. This raises the risk of adverse effects including hepatotoxicity.
معنای این تداخل به زبان ساده
Fezolinetant and Fluvoxamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fezolinetant belongs to Endocrine; Fluvoxamine belongs to Central Nervous System.
چرا رخ می‌دهد
Strong CYP1A2 inhibition by fluvoxamine markedly reduces fezolinetant clearance.
اقدام لازم
Do not use together; choose a different antidepressant or vasomotor symptom treatment. If fezolinetant is used, monitor liver tests per labeling.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Fezolinetant و Fluvoxamine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Fluvoxamine
- Agomelatine + Fluvoxamine منع مصرف
- Alosetron + Fluvoxamine منع مصرف
- Fluvoxamine + Isocarboxazid منع مصرف
- Fluvoxamine + Mavacamten منع مصرف
- Fluvoxamine + Methylene blue منع مصرف
- Fluvoxamine + Phenelzine منع مصرف
تداخلات دیگر Fezolinetant
- Cimetidine + Fezolinetant منع مصرف
- Ciprofloxacin + Fezolinetant منع مصرف
- Desogestrel-ethinyl estradiol + Fezolinetant منع مصرف
- Estradiol + Fezolinetant منع مصرف
- Ethinyl estradiol-drospirenone + Fezolinetant منع مصرف
- Ethinyl estradiol-levonorgestrel + Fezolinetant منع مصرف
پرسش‌های متداول
Can I take Fezolinetant with Fluvoxamine?
MediHelp rates the interaction as contraindicated. Fezolinetant and Fluvoxamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fezolinetant is metabolised mainly by CYP1A2, and fluvoxamine is a strong CYP1A2 inhibitor that greatly increases its exposure. This raises the risk of adverse effects including hepatotoxicity.
How serious is the interaction between Fezolinetant and Fluvoxamine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose a different antidepressant or vasomotor symptom treatment. If fezolinetant is used, monitor liver tests per labeling.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Isocarboxazid. The full list is on the Fluvoxamine page.
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