تداخل‌های دارویی
Fluvoxamine + Tizanidine
شدت: منع مصرف
Fluvoxamine and Tizanidine: contraindicated interaction.
آخرین به‌روزرسانی منابع: US FDA label
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Fluvoxamine markedly raises tizanidine concentrations, producing severe hypotension, bradycardia, profound sedation and psychomotor impairment. Tizanidine labeling contraindicates concomitant use with strong CYP1A2 inhibitors such as fluvoxamine. The effect is large and well documented.
معنای این تداخل به زبان ساده
Fluvoxamine and Tizanidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fluvoxamine belongs to Central Nervous System; Tizanidine belongs to Musculoskeletal.
چرا رخ می‌دهد
Fluvoxamine is a potent CYP1A2 inhibitor and blocks the principal clearance pathway of tizanidine, causing a large increase in exposure.
اقدام لازم
Do not combine. Use a different antispasticity or muscle-relaxant agent such as baclofen, or an antidepressant that does not strongly inhibit CYP1A2 (for example sertraline or escitalopram).
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Fluvoxamine و Tizanidine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
منابع
تداخلات دیگر Tizanidine
تداخلات دیگر Fluvoxamine
- Agomelatine + Fluvoxamine منع مصرف
- Alosetron + Fluvoxamine منع مصرف
- Fezolinetant + Fluvoxamine منع مصرف
- Fluvoxamine + Isocarboxazid منع مصرف
- Fluvoxamine + Mavacamten منع مصرف
- Fluvoxamine + Methylene blue منع مصرف
پرسش‌های متداول
Can I take Fluvoxamine with Tizanidine?
MediHelp rates the interaction as contraindicated. Fluvoxamine and Tizanidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fluvoxamine markedly raises tizanidine concentrations, producing severe hypotension, bradycardia, profound sedation and psychomotor impairment. Tizanidine labeling contraindicates concomitant use with strong CYP1A2 inhibitors such as fluvoxamine. The effect is large and well documented.
How serious is the interaction between Fluvoxamine and Tizanidine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Use a different antispasticity or muscle-relaxant agent such as baclofen, or an antidepressant that does not strongly inhibit CYP1A2 (for example sertraline or escitalopram).
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Pefloxacin, Pipemidic acid. The full list is on the Tizanidine page.
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