تداخل‌های دارویی
Hydromorphone + Isocarboxazid
شدت: منع مصرف
Hydromorphone and Isocarboxazid: contraindicated interaction.
آخرین به‌روزرسانی
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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Opioids combined with nonselective MAOIs have caused serious reactions including hypotension, hyperthermia, agitation, coma and respiratory depression. Hydromorphone labeling advises against use with MAOIs or within 14 days of stopping them.
معنای این تداخل به زبان ساده
Hydromorphone and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Hydromorphone belongs to Musculoskeletal; Isocarboxazid belongs to Central Nervous System.
چرا رخ می‌دهد
Irreversible MAO inhibition may potentiate opioid CNS and respiratory depression and cause serotonergic or autonomic instability; the exact mechanism is not fully defined.
اقدام لازم
Do not use together and allow at least 14 days after stopping the MAOI before starting hydromorphone. Use a non-serotonergic alternative analgesic if needed.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Hydromorphone و Isocarboxazid، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Hydromorphone
- Alvimopan + Hydromorphone منع مصرف
- Bupropion-naltrexone + Hydromorphone منع مصرف
- Hydromorphone + Olanzapine / samidorphan منع مصرف
- Hydromorphone + Phenelzine منع مصرف
- Hydromorphone + Tranylcypromine منع مصرف
- Alfentanil + Hydromorphone شدید
تداخلات دیگر Isocarboxazid
- 5-HTP + Isocarboxazid منع مصرف
- Amitriptyline + Isocarboxazid منع مصرف
- Amobarbital + Isocarboxazid منع مصرف
- Amoxapine + Isocarboxazid منع مصرف
- Apraclonidine + Isocarboxazid منع مصرف
- Atomoxetine + Isocarboxazid منع مصرف
پرسش‌های متداول
Can I take Hydromorphone with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Hydromorphone and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Opioids combined with nonselective MAOIs have caused serious reactions including hypotension, hyperthermia, agitation, coma and respiratory depression. Hydromorphone labeling advises against use with MAOIs or within 14 days of stopping them.
How serious is the interaction between Hydromorphone and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together and allow at least 14 days after stopping the MAOI before starting hydromorphone. Use a non-serotonergic alternative analgesic if needed.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Olanzapine / samidorphan. The full list is on the Hydromorphone page.
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