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تداخل‌های دارویی

Leflunomide + Ublituximab

شدت: شدید

Leflunomide and Ublituximab: major interaction.

آخرین به‌روزرسانی

ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.

محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Both drugs suppress immune function, so combined use may increase the risk of serious infections. The risk is greater because leflunomide's active metabolite persists for a long time.

معنای این تداخل به زبان ساده

Leflunomide and Ublituximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Leflunomide belongs to Musculoskeletal; Ublituximab belongs to Miscellaneous.

سطح شواهد: Moderate

چرا رخ می‌دهد

Additive immunosuppression from B-cell depletion by ublituximab and lymphocyte antiproliferation by leflunomide.

اقدام لازم

Avoid combining where possible. If used together, monitor closely for infection, and consider the long persistence of teriflunomide, using accelerated elimination if needed.

از داروساز چه بپرسید

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Leflunomide و Ublituximab، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Leflunomide with Ublituximab?

MediHelp rates the interaction as major. Leflunomide and Ublituximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs suppress immune function, so combined use may increase the risk of serious infections. The risk is greater because leflunomide's active metabolite persists for a long time.

How serious is the interaction between Leflunomide and Ublituximab?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible. If used together, monitor closely for infection, and consider the long persistence of teriflunomide, using accelerated elimination if needed.

What other medicines interact with Leflunomide?

MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.

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