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Levodopa + Phenelzine (nonselective MAOI)

شدت: منع مصرف

Levodopa and Phenelzine (nonselective MAOI): contraindicated interaction.

آخرین به‌روزرسانی منابع: US FDA label

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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Levodopa with a nonselective MAOI such as phenelzine can cause hypertensive crisis because peripheral dopamine and norepinephrine accumulate. Levodopa labeling contraindicates nonselective MAOIs, which must be stopped at least two weeks beforehand. Severe headache, palpitations and dangerously high blood pressure may occur.

معنای این تداخل به زبان ساده

Levodopa and Phenelzine (nonselective MAOI) are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

سطح شواهد: High

چرا رخ می‌دهد

Nonselective MAO inhibition blocks breakdown of dopamine and norepinephrine formed from levodopa, causing excessive catecholamine accumulation and a pressor response.

اقدام لازم

Do not combine. Stop phenelzine at least 14 days before starting levodopa.

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Levodopa و Phenelzine (nonselective MAOI)، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

منابع

پرسش‌های متداول

Can I take Levodopa with Phenelzine (nonselective MAOI)?

MediHelp rates the interaction as contraindicated. Levodopa and Phenelzine (nonselective MAOI) are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levodopa with a nonselective MAOI such as phenelzine can cause hypertensive crisis because peripheral dopamine and norepinephrine accumulate. Levodopa labeling contraindicates nonselective MAOIs, which must be stopped at least two weeks beforehand. Severe headache, palpitations and dangerously high blood pressure may occur.

How serious is the interaction between Levodopa and Phenelzine (nonselective MAOI)?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Stop phenelzine at least 14 days before starting levodopa.

What other medicines interact with Levodopa?

MediHelp also lists interactions of Levodopa with, for example, Isocarboxazid, Phenelzine, Procarbazine. The full list is on the Levodopa page.

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