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تداخل‌های دارویی

Levodopa + Tranylcypromine

شدت: منع مصرف

Levodopa and Tranylcypromine: contraindicated interaction.

آخرین به‌روزرسانی

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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Levodopa is converted to dopamine and norepinephrine, and nonselective MAO inhibition prevents their breakdown. This can produce hypertensive crisis with severe headache and cardiovascular events.

معنای این تداخل به زبان ساده

Levodopa and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Levodopa belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.

سطح شواهد: High

چرا رخ می‌دهد

Increased catecholamine formation with blocked MAO-A and MAO-B degradation causes exaggerated pressor effects.

اقدام لازم

Avoid the combination and stop the nonselective MAOI at least 14 days before starting levodopa. Selective MAO-B inhibitors are used in Parkinson disease under guidance.

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Levodopa و Tranylcypromine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Levodopa with Tranylcypromine?

MediHelp rates the interaction as contraindicated. Levodopa and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levodopa is converted to dopamine and norepinephrine, and nonselective MAO inhibition prevents their breakdown. This can produce hypertensive crisis with severe headache and cardiovascular events.

How serious is the interaction between Levodopa and Tranylcypromine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and stop the nonselective MAOI at least 14 days before starting levodopa. Selective MAO-B inhibitors are used in Parkinson disease under guidance.

What other medicines interact with Tranylcypromine?

MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.

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