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تداخل‌های دارویی

Levodopa + Phenelzine

شدت: منع مصرف

Levodopa and Phenelzine: contraindicated interaction.

آخرین به‌روزرسانی

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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Levodopa is converted to dopamine and norepinephrine, and a nonselective MAO inhibitor prevents their breakdown. The combination can produce sudden severe hypertension and hypertensive crisis. Labeling for levodopa products contraindicates concurrent nonselective MAOIs.

معنای این تداخل به زبان ساده

Levodopa and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Levodopa belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.

سطح شواهد: High

چرا رخ می‌دهد

Irreversible MAO inhibition by phenelzine blocks catecholamine degradation, so levodopa-derived dopamine and norepinephrine accumulate.

اقدام لازم

Do not combine; stop phenelzine at least 14 days before starting levodopa. Choose a non-MAOI antidepressant if one is needed in a patient on levodopa.

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Levodopa و Phenelzine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Levodopa with Phenelzine?

MediHelp rates the interaction as contraindicated. Levodopa and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levodopa is converted to dopamine and norepinephrine, and a nonselective MAO inhibitor prevents their breakdown. The combination can produce sudden severe hypertension and hypertensive crisis. Labeling for levodopa products contraindicates concurrent nonselective MAOIs.

How serious is the interaction between Levodopa and Phenelzine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; stop phenelzine at least 14 days before starting levodopa. Choose a non-MAOI antidepressant if one is needed in a patient on levodopa.

What other medicines interact with Phenelzine?

MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.

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