Référentiel des médicaments
Cangrelor
Cangrelor is a medicine in the class cardiovascular. It is used for coronary artery stent thrombosis.
- Classe médicamenteuse: Cardiovascular
- Indications: coronary artery stent thrombosis
Dernière mise à jour Sources: US FDA label
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L'essentiel
- Classe médicamenteuse
- Cardiovascular
- Formes courantes
- injection
- Dosages courants
- 50 mg
- Interactions connues
- 3 (Majeure: 2 · Modérée: 1)
- Noms commerciaux
- 2
- Pays et marchés
- 2
Indications
Mécanisme d'action
Direct P2Y12 platelet receptor inhibitor that blocks ADP-induced platelet activation and aggregation; binds selectively and reversibly to the P2Y12 receptor.
Posologie adulte habituelle (résumé de la notice)
Adjunct to PCI: 30 mcg/kg IV bolus before PCI, followed immediately by 4 mcg/kg/min IV infusion for at least 2 hours or the duration of PCI, whichever is longer.
Grossesse et allaitement
- Grossesse
- Unknown No human data. Animal studies showed no malformations, but fetal growth retardation and increased abortion/intrauterine losses occurred at higher doses. May increase maternal bleeding during labor and delivery.
- Allaitement
- Unknown No data on presence in milk; exposure in the breastfed infant is expected to be very low due to short half-life.
Effets indésirables signalés
- Bleeding
- Dyspnea
- Hypersensitivity reactions (anaphylaxis, bronchospasm, angioedema, stridor)
- Worsening renal function in severe renal impairment
Contre-indications
- Significant active bleeding.
- Known hypersensitivity (e.g., anaphylaxis) to cangrelor or any component of the product.
Précautions particulières
- Bleeding risk: P2Y12 inhibitors including cangrelor increase bleeding risk; bleeding events of all severities were more common than with clopidogrel. No antiplatelet effect after an hour once discontinued.
- Neuraxial blockade is not advised during use because of potential spinal hematoma risk; discontinue 1 hour before labor, delivery, or neuraxial blockade when possible.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (3)
- Cangrelor + Clopidogrel Major
- Cangrelor + Prasugrel Major
- Cangrelor + Warfarin Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- IV preparation and dilution
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Questions fréquentes
What is Cangrelor used for?
Cangrelor is a medicine in the class cardiovascular. It is used for Coronary artery stent thrombosis, Myocardial infarction.
What side effects have been reported with Cangrelor?
Bleeding, Dyspnea, Hypersensitivity reactions (anaphylaxis, bronchospasm, angioedema, stridor), Worsening renal function in severe renal impairment.
Can Cangrelor be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No human data. Animal studies showed no malformations, but fetal growth retardation and increased abortion/intrauterine losses occurred at higher doses. May increase maternal bleeding during labor and delivery. Breastfeeding: Unknown. No data on presence in milk; exposure in the breastfed infant is expected to be very low due to short half-life.
What does Cangrelor interact with?
MediHelp lists 3 known interactions for Cangrelor. Major: 2 · Moderate: 1. The most serious include Clopidogrel, Prasugrel, Warfarin.
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