Interactions médicamenteuses
Cangrelor + Prasugrel
Gravité: Majeure
Cangrelor and Prasugrel: major interaction.
Dernière mise à jour
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Résumé
Cangrelor reversibly blocks the platelet P2Y12 receptor and can prevent the active metabolite of prasugrel from binding if given during the infusion. This results in loss of the intended antiplatelet effect of prasugrel and a risk of stent thrombosis.
Ce que signifie cette interaction, en termes simples
Cangrelor and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cangrelor belongs to Cardiovascular; Prasugrel belongs to Cardiovascular.
Pourquoi elle survient
Competition at the P2Y12 receptor, where cangrelor occupies the binding site and blocks the irreversible binding of prasugrel's active metabolite.
Conduite à tenir
Give prasugrel only after the cangrelor infusion has been discontinued, not during it.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Cangrelor
- Cangrelor + Clopidogrel Majeure
- Cangrelor + Warfarin Modérée
Autres interactions de Prasugrel
- Acetylsalicylic acid + Prasugrel Majeure
- Apixaban + Prasugrel Majeure
- Argatroban + Prasugrel Majeure
- Celecoxib + Prasugrel Majeure
- Dabigatran etexilate + Prasugrel Majeure
- Dalteparin + Prasugrel Majeure
Questions fréquentes
Can I take Cangrelor with Prasugrel?
MediHelp rates the interaction as major. Cangrelor and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cangrelor reversibly blocks the platelet P2Y12 receptor and can prevent the active metabolite of prasugrel from binding if given during the infusion. This results in loss of the intended antiplatelet effect of prasugrel and a risk of stent thrombosis.
How serious is the interaction between Cangrelor and Prasugrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give prasugrel only after the cangrelor infusion has been discontinued, not during it.
What other medicines interact with Cangrelor?
MediHelp also lists interactions of Cangrelor with, for example, Clopidogrel, Warfarin. The full list is on the Cangrelor page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
