Référentiel des médicaments
Prasugrel
Prasugrel is a medicine in the class cardiovascular. It is used for acute coronary syndrome.
- Classe médicamenteuse: Cardiovascular
- Indications: acute coronary syndrome
Dernière mise à jour Sources: US FDA label
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L'essentiel
- Classe médicamenteuse
- Cardiovascular
- Code ATC
- B01AC22
- Formes courantes
- comprimé
- Interactions connues
- 51 (Majeure: 34 · Modérée: 15 · Mineure: 2)
- Noms commerciaux
- 3
- Pays et marchés
- 2
Indications
Mécanisme d'action
Prasugrel's active metabolite binds irreversibly to the P2Y12 class of ADP receptors on platelets, inhibiting platelet activation and aggregation.
Posologie adulte habituelle (résumé de la notice)
Acute coronary syndrome managed with PCI: 60 mg oral loading dose, then 10 mg orally once daily, with or without food; take with aspirin 75 mg to 325 mg daily
Grossesse et allaitement
- Grossesse
- Unknown No human data. No structural malformations in animals. Consider benefits and risks to the fetus given the bleeding risk.
- Allaitement
- Unknown No information on presence in human milk; metabolites found in rat milk. Weigh benefits of breastfeeding against maternal need.
Effets indésirables signalés
- Bleeding (including life-threatening and fatal)
- Epistaxis
- Gastrointestinal hemorrhage
- Hemoptysis
- Subcutaneous hematoma
- Post-procedural hemorrhage
Mises en garde encadrées
- Effient can cause significant, sometimes fatal, bleeding. Do not use in patients with active pathological bleeding or a history of TIA or stroke. In patients ≥75 years it is generally not recommended, except in high-risk patients (diabetes or prior MI). Do not start in patients likely to undergo urgent CABG; when possible discontinue at least 7 days before any surgery. Other bleeding risk factors: body weight <60 kg, propensity to bleed, and concomitant medications that increase bleeding risk. Suspect bleeding in hypotensive patients after invasive or surgical procedures. If possible, manage…
Contre-indications
- Active pathological bleeding such as peptic ulcer or intracranial hemorrhage
- History of prior transient ischemic attack or stroke
- Hypersensitivity (e.g., anaphylaxis) to prasugrel or any component of the product
Précautions particulières
- Thienopyridines increase bleeding risk, which is highest initially; suspect bleeding in hypotensive patients after procedures
- CABG-related bleeding risk is increased; discontinue at least 7 days before CABG if possible
- Premature discontinuation increases risk of stent thrombosis, MI and death; avoid lapses in therapy
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (51)
- Acetylsalicylic acid + Prasugrel Major
- Apixaban + Prasugrel Major
- Argatroban + Prasugrel Major
- Cangrelor + Prasugrel Major
- Celecoxib + Prasugrel Major
- Dabigatran etexilate + Prasugrel Major
- Dalteparin + Prasugrel Major
- Deferasirox + Prasugrel Major
- Diclofenac + Prasugrel Major
- Diflunisal + Prasugrel Major
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
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- Pharmacokinetics
- Patient counselling points
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Questions fréquentes
What is Prasugrel used for?
Prasugrel is a medicine in the class cardiovascular. It is used for Acute coronary syndrome.
What side effects have been reported with Prasugrel?
Bleeding (including life-threatening and fatal), Epistaxis, Gastrointestinal hemorrhage, Hemoptysis, Subcutaneous hematoma, Post-procedural hemorrhage. Serious warning: Effient can cause significant, sometimes fatal, bleeding.
Can Prasugrel be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No human data. No structural malformations in animals. Consider benefits and risks to the fetus given the bleeding risk. Breastfeeding: Unknown. No information on presence in human milk; metabolites found in rat milk. Weigh benefits of breastfeeding against maternal need.
What does Prasugrel interact with?
MediHelp lists 51 known interactions for Prasugrel. Major: 34 · Moderate: 15 · Minor: 2. The most serious include Acetylsalicylic acid, Apixaban, Argatroban.
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