Référentiel des médicaments
Eravacycline
Eravacycline is a medicine in the class anti bacterial. It is used for intra-abdominal infections.
- Classe médicamenteuse: Anti Bacterial
- Indications: intra-abdominal infections
Dernière mise à jour Sources: US FDA label
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L'essentiel
- Classe médicamenteuse
- Anti Bacterial
- Code ATC
- J01AA13
- Formes courantes
- injection
- Interactions connues
- 5 (Modérée: 5)
- Noms commerciaux
- 2
- Pays et marchés
- 2
Indications
Mécanisme d'action
Eravacycline is an antibacterial drug (tetracycline class); the label gives no further mechanism detail.
Posologie adulte habituelle (résumé de la notice)
Complicated intra-abdominal infection (adults 18 years and older): 1 mg/kg IV infusion over approximately 60 minutes every 12 hours for a total of 4 to 14 days, guided by severity, location and clinical response.
Grossesse et allaitement
- Grossesse
- Unsafe May cause tooth discoloration and reversible inhibition of bone growth if given in the second and third trimester; limited human data. Tetracyclines can have toxic effects on the developing fetus.
- Allaitement
- Unsafe Not known if excreted in human milk; breastfeeding is not recommended during treatment and for 4 days after the last dose.
Effets indésirables signalés
- Infusion site reactions
- Nausea
- Vomiting
- Diarrhea
- Hypotension
- Wound dehiscence
Contre-indications
- Known hypersensitivity to eravacycline, tetracycline-class antibacterial drugs, or any excipients.
Précautions particulières
- Life-threatening hypersensitivity (anaphylactic) reactions reported; avoid in patients with known tetracycline hypersensitivity and discontinue if an allergic reaction occurs.
- Use during tooth development (last half of pregnancy, infancy, childhood to age 8 years) may cause permanent tooth discoloration and enamel hypoplasia.
- Use during the second and third trimester of pregnancy, infancy and childhood up to age 8 years may cause reversible inhibition of bone growth.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (5)
- Amoxicillin + Eravacycline Moderate
- Amoxicillin-clavulanic acid + Eravacycline Moderate
- Ampicillin + Eravacycline Moderate
- Ampicillin-sulbactam + Eravacycline Moderate
- Eravacycline + Warfarin Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
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Questions fréquentes
What is Eravacycline used for?
Eravacycline is a medicine in the class anti bacterial. It is used for Intra-abdominal infections.
What side effects have been reported with Eravacycline?
Infusion site reactions, Nausea, Vomiting, Diarrhea, Hypotension, Wound dehiscence.
Can Eravacycline be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. May cause tooth discoloration and reversible inhibition of bone growth if given in the second and third trimester; limited human data. Tetracyclines can have toxic effects on the developing fetus. Breastfeeding: Unsafe. Not known if excreted in human milk; breastfeeding is not recommended during treatment and for 4 days after the last dose.
What does Eravacycline interact with?
MediHelp lists 5 known interactions for Eravacycline. Moderate: 5. The most serious include Amoxicillin, Amoxicillin-clavulanic acid, Ampicillin.
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