Référentiel des médicaments
Tigecycline
Tigecycline is a medicine in the class anti bacterial. It is used for intra-abdominal infections.
- Classe médicamenteuse: Anti Bacterial
- Indications: intra-abdominal infections
Dernière mise à jour
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L'essentiel
- Classe médicamenteuse
- Anti Bacterial
- Code ATC
- J01AA12
- Formes courantes
- injection, perfusion
- Dosages courants
- 50 mg, 50 mg/5 ml
- Interactions connues
- 17 (Majeure: 1 · Modérée: 5 · Mineure: 11)
- Noms commerciaux
- 12
- Pays et marchés
- 5
Indications
Mécanisme d'action
A glycylcycline antibiotic that is structurally similar to tetracycline antibiotics; inhibits bacterial protein translation by binding to 30S ribosomal subunit, and blocks entry of amino-acyl tRNA molecules in ribosome A site.
Posologie adulte habituelle (résumé de la notice)
Complicated Intra-abdominal Infections (Initial): 100 mg IV infusion, THEN 50 mg IV infusion q12hr for 5-14 days
Grossesse et allaitement
- Grossesse
- Unsafe Like other tetracyclines it may permanently discolour the baby's teeth and slow bone growth when given in the 2nd or 3rd trimester; skeletal delays in rats and rabbits at 1 to 5 times human exposure. UK label: do not use unless the mother's condition requires it. Prefer another antibiotic.
- Allaitement
- Safe No human milk data; poorly absorbed orally, so infant exposure is expected to be low. US label: avoid breastfeeding for courses over 3 weeks; may pump and discard during and for 9 days after. LactMed: short courses probably acceptable; watch for rash, diarrhoea or thrush.
Effets indésirables signalés
- Vomiting
- Diarrhea
- Nausea
- Infection
- Fever
Précautions particulières
- Prescribing therapy in absence of a proven or strongly suspected bacterial infection is unlikely to provide benefit to patient
- May cause fetal harm when administered to a pregnant woman
- Increases in total bilirubin concentration, prothrombin time and transaminases reported in patients treated with tigecycline;
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (17)
- Tigecycline + Typhoid vaccine live Major
- Bcg vaccine live + Tigecycline Moderate
- Cholera vaccine + Tigecycline Moderate
- Microbiota + Tigecycline Moderate
- Mipomersen + Tigecycline Moderate
- Sodium picosulfate / magnesium oxide / anhydrous citric acid + Tigecycline Moderate
- Balsalazide + Tigecycline Minor
- Bazedoxifene / conjugated estrogens + Tigecycline Minor
- Conjugated estrogens + Tigecycline Minor
- Desogestrel-ethinyl estradiol + Tigecycline Minor
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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Questions fréquentes
What is Tigecycline used for?
Tigecycline is a medicine in the class anti bacterial. It is used for Intra-abdominal infections, Pneumonia, Skin infections.
What side effects have been reported with Tigecycline?
Vomiting, Diarrhea, Nausea, Infection, Fever.
Can Tigecycline be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Like other tetracyclines it may permanently discolour the baby's teeth and slow bone growth when given in the 2nd or 3rd trimester; skeletal delays in rats and rabbits at 1 to 5 times human exposure. UK label: do not use unless the mother's condition requires it. Prefer another antibiotic. Breastfeeding: Safe. No human milk data; poorly absorbed orally, so infant exposure is expected to be low. US label: avoid breastfeeding for courses over 3 weeks; may pump and discard during and for 9 days after. LactMed: short courses probably acceptable; watch for rash, diarrhoea or thrush.
What does Tigecycline interact with?
MediHelp lists 17 known interactions for Tigecycline. Major: 1 · Moderate: 5 · Minor: 11. The most serious include Typhoid vaccine live, Bcg vaccine live, Cholera vaccine.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
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