Référentiel des médicaments
Isavuconazonium
Isavuconazonium is a medicine in the class anti fungals. It is used for aspergillosis.
- Classe médicamenteuse: Anti Fungals
- Indications: aspergillosis
Dernière mise à jour Sources: US FDA label
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Le contenu clinique de cette page n'est disponible qu'en anglais.
L'essentiel
- Classe médicamenteuse
- Anti Fungals
- Formes courantes
- gélule, injection
- Interactions connues
- 147 (Contre-indiquée: 11 · Majeure: 15 · Modérée: 78 · Mineure: 43)
- Noms commerciaux
- 1
- Pays et marchés
- 1
Indications
Mécanisme d'action
Isavuconazonium sulfate is a prodrug of isavuconazole, an azole antifungal.
Posologie adulte habituelle (résumé de la notice)
Invasive aspergillosis/mucormycosis, IV: loading dose 372 mg (one reconstituted vial) every 8 hours for 6 doses (48 hours); then 372 mg once daily, starting 12 to 24 hours after last loading dose
Grossesse et allaitement
- Grossesse
- Unsafe May cause fetal harm based on animal studies; no human data. Use effective contraception during treatment and for 28 days after final dose.
- Allaitement
- Unsafe No human milk data; present in rat milk. Breastfeeding should be discontinued during treatment.
Effets indésirables signalés
- Nausea
- Vomiting
- Diarrhea
- Headache
- Elevated liver chemistry tests
- Hypokalemia
Contre-indications
- Known hypersensitivity to isavuconazole.
- Coadministration with strong CYP3A4 inhibitors such as ketoconazole or high-dose ritonavir (400 mg every 12 hours).
- Coadministration with strong CYP3A4 inducers such as rifampin, carbamazepine, St. John's wort, or long acting barbiturates.
Précautions particulières
- Hepatic adverse reactions, including hepatitis, cholestasis, hepatic failure; check liver tests at start and during therapy.
- Infusion-related reactions with IV use; discontinue infusion if they occur.
- Anaphylaxis (some fatal) reported; discontinue if anaphylactic or severe skin reactions occur.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (147)
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Isavuconazonium + Ketoconazole Contraindicated
- Isavuconazonium + Phenytoin Contraindicated
- Isavuconazonium + Pimozide Contraindicated
- Isavuconazonium + Rifampicin Contraindicated
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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Questions fréquentes
What is Isavuconazonium used for?
Isavuconazonium is a medicine in the class anti fungals. It is used for Aspergillosis.
What side effects have been reported with Isavuconazonium?
Nausea, Vomiting, Diarrhea, Headache, Elevated liver chemistry tests, Hypokalemia.
Can Isavuconazonium be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. May cause fetal harm based on animal studies; no human data. Use effective contraception during treatment and for 28 days after final dose. Breastfeeding: Unsafe. No human milk data; present in rat milk. Breastfeeding should be discontinued during treatment.
What does Isavuconazonium interact with?
MediHelp lists 147 known interactions for Isavuconazonium. Contraindicated: 11 · Major: 15 · Moderate: 78 · Minor: 43. The most serious include Amobarbital, Apalutamide, Carbamazepine.
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