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Interactions médicamenteuses

Cisapride + Isavuconazonium

Gravité: Contre-indiquée

Cisapride and Isavuconazonium: contraindicated interaction.

Dernière mise à jour

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Résumé

Isavuconazole, the active moiety, is a moderate CYP3A4 inhibitor and raises cisapride exposure. Because cisapride is a CYP3A4 substrate with serious QT risk, higher levels may provoke torsades de pointes. Cisapride does not meaningfully affect isavuconazole.

Ce que signifie cette interaction, en termes simples

Cisapride and Isavuconazonium are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Cisapride belongs to Gastrointestinal Tract; Isavuconazonium belongs to Anti Fungals.

Niveau de preuve: Moderate

Pourquoi elle survient

Inhibition of CYP3A4-mediated cisapride metabolism by isavuconazole, increasing cisapride concentrations and QT prolongation.

Conduite à tenir

Avoid the combination; use an alternative prokinetic or antifungal.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cisapride with Isavuconazonium?

MediHelp rates the interaction as contraindicated. Cisapride and Isavuconazonium are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Isavuconazole, the active moiety, is a moderate CYP3A4 inhibitor and raises cisapride exposure. Because cisapride is a CYP3A4 substrate with serious QT risk, higher levels may provoke torsades de pointes. Cisapride does not meaningfully affect isavuconazole.

How serious is the interaction between Cisapride and Isavuconazonium?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an alternative prokinetic or antifungal.

What other medicines interact with Cisapride?

MediHelp also lists interactions of Cisapride with, for example, Apomorphine, Artemether, Azithromycin. The full list is on the Cisapride page.

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