Référentiel des médicaments
Clotrimazole
Clotrimazole is a medicine in the class anti fungals. It is used for candidiasis.
- Classe médicamenteuse: Anti Fungals
- Indications: candidiasis
Dernière mise à jour Sources: US FDA label, UK SmPC
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L'essentiel
- Classe médicamenteuse
- Anti Fungals
- Formes courantes
- crème, solution, comprimé, pommade, spray, poudre
- Dosages courants
- 1 g/100 g, 10 mg/g, 1%
- Interactions connues
- 32 (Majeure: 4 · Modérée: 19 · Mineure: 9)
- Noms commerciaux
- 176
- Pays et marchés
- 5
Indications
Mécanisme d'action
Antifungal activity Alters cell membrane permeability, apparently by binding with phospholipids in the fungal cell membrane, causing essential intracellular elements to leak
Posologie adulte habituelle (résumé de la notice)
Opharyngeal candidiasis (prophylaxis): 10 mg PO slowly dissolved in mouth tid or until steroids reduced to maintenance levels
Grossesse et allaitement
- Grossesse
- Safe Vaginal, skin and mouth forms give very little absorption, and studies show no rise in birth defects. A 7-day vaginal course is a preferred treatment for thrush in pregnancy; in late pregnancy insert pessaries by hand or with care.
- Allaitement
- Safe Very little is absorbed from skin, vagina or mouth, so it is not expected in milk in meaningful amounts. Compatible with breastfeeding. If used on the nipple for thrush, wipe off before feeds.
Effets indésirables signalés
- Edema
- Pruritus
- Erythema
- Blistering
Contre-indications
- Hypersensitivity to clotrimazole or to any of the excipients in the formulation.
Précautions particulières
- Condoms and diagrams may damage and fail to prevent pregnancy or sexually transmitted disease
- Not for use when having vaginal intercourse
- May cause mild increase in vaginal burning, itching or irritation
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (32)
- Clotrimazole + Lomitapide Major
- Clotrimazole + Mavacamten Major
- Clotrimazole + Mobocertinib Major
- Clotrimazole + Voclosporin Major
- Bosutinib + Clotrimazole Moderate
- Cannabidiol + Clotrimazole Moderate
- Clotrimazole + Cyclosporine Moderate
- Clotrimazole + Eliglustat Moderate
- Clotrimazole + Entrectinib Moderate
- Clotrimazole + Everolimus Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Autres médicaments de cette classe
Questions fréquentes
What is Clotrimazole used for?
Clotrimazole is a medicine in the class anti fungals. It is used for Candidiasis, Superficial dermatologic infection, Tinea, Vulvovaginal candidiasis.
What side effects have been reported with Clotrimazole?
Edema, Pruritus, Erythema, Blistering.
Can Clotrimazole be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. Vaginal, skin and mouth forms give very little absorption, and studies show no rise in birth defects. A 7-day vaginal course is a preferred treatment for thrush in pregnancy; in late pregnancy insert pessaries by hand or with care. Breastfeeding: Safe. Very little is absorbed from skin, vagina or mouth, so it is not expected in milk in meaningful amounts. Compatible with breastfeeding. If used on the nipple for thrush, wipe off before feeds.
What does Clotrimazole interact with?
MediHelp lists 32 known interactions for Clotrimazole. Major: 4 · Moderate: 19 · Minor: 9. The most serious include Lomitapide, Mavacamten, Mobocertinib.
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