Interactions médicamenteuses
Pentostatin + Tofacitinib
Gravité: Majeure
Pentostatin and Tofacitinib: major interaction.
Dernière mise à jour
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Résumé
Pentostatin causes profound lymphocyte depletion and immunosuppression, so combining it with tofacitinib increases the risk of severe and opportunistic infections. Pentostatin also has other toxicities such as renal and neurologic effects.
Ce que signifie cette interaction, en termes simples
Pentostatin and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pentostatin belongs to Oncology; Tofacitinib belongs to Musculoskeletal.
Pourquoi elle survient
Additive immunosuppression from JAK inhibition and adenosine deaminase inhibition causing lymphocyte toxicity.
Conduite à tenir
Avoid concurrent use and consider holding tofacitinib during pentostatin therapy. If both are needed, monitor for infection and consider prophylaxis.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Tofacitinib
- Baricitinib + Tofacitinib Contre-indiquée
- Cladribine + Tofacitinib Contre-indiquée
- Tofacitinib + Upadacitinib Contre-indiquée
- Abatacept + Tofacitinib Majeure
- Anti-thymocyte + Tofacitinib Majeure
- Antithymocyte globulin equine + Tofacitinib Majeure
Autres interactions de Pentostatin
- Carmustine + Pentostatin Contre-indiquée
- Etoposide + Pentostatin Contre-indiquée
- Fludarabine + Pentostatin Contre-indiquée
- Cyclophosphamide + Pentostatin Majeure
- Deferiprone + Pentostatin Majeure
- Fingolimod + Pentostatin Majeure
Questions fréquentes
Can I take Pentostatin with Tofacitinib?
MediHelp rates the interaction as major. Pentostatin and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pentostatin causes profound lymphocyte depletion and immunosuppression, so combining it with tofacitinib increases the risk of severe and opportunistic infections. Pentostatin also has other toxicities such as renal and neurologic effects.
How serious is the interaction between Pentostatin and Tofacitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and consider holding tofacitinib during pentostatin therapy. If both are needed, monitor for infection and consider prophylaxis.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
