Référentiel des médicaments
Scopolamine
Scopolamine is a medicine in the class respiratory. It is used for irritable bowel syndrome.
- Classe médicamenteuse: Respiratory
- Indications: irritable bowel syndrome
Dernière mise à jour
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L'essentiel
- Classe médicamenteuse
- Respiratory
- Formes courantes
- patch, comprimé
- Dosages courants
- 10 mg, 5 mg/5 ml, 1 mg
- Interactions connues
- 143 (Majeure: 17 · Modérée: 105 · Mineure: 21)
- Noms commerciaux
- 19
- Pays et marchés
- 3
Indications
Mécanisme d'action
Its anticholinergic action exerts a smooth-muscle relaxing/spasmolytic effect. Blockade of the muscarinic receptors in the GI tract is the basis for its use in the treatment of abdominal pain secondary to cramping. Hyoscine butylbromide also binds to nicotinic receptors, which induces a ganglion-blocking effect.
Posologie adulte habituelle (résumé de la notice)
Nausea & Vomiting (Treatment): 0.3-0.65 mg IV/IM/SC; repeat q6-8hr if necessary
Grossesse et allaitement
- Grossesse
- Unknown Covers hyoscine butylbromide (Buscopan, poorly absorbed by mouth) and hyoscine hydrobromide (patch, tablets). US patch label: no rise in birth defects in observational data; avoid in severe pre-eclampsia (seizures after injection). UK Buscopan: not recommended in pregnancy as a precaution.
- Allaitement
- Safe Hyoscine passes into milk. LactMed: a single dose is unlikely to affect breastfeeding, but long-term use may reduce milk supply or let-down; watch for poor feeding and weight gain. UK Buscopan: not recommended while breastfeeding (no data).
Effets indésirables signalés
- Drowsiness
- Dry mouth
- Blurred vision
- Dizziness
- Disorientation
Contre-indications
- Hypersensitivity to scopolamine, belladonna alkaloids, or any component in formulation
- Closed-angle glaucoma
Précautions particulières
- Use caution in patients with benign prostatic hyperplasia, history of seizures or psychosis, ulcerative colitis, hypertension, hyperthyroidism.
- Scopolamine tablets have been discontinued, but Hyoscine N-Butylbromide is still in market.
- May cause CNS depression; caution when operating heavy machinery or tasks which require mental alertness
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (143)
- Benzhydrocodone / acetaminophen + Scopolamine Major
- Buprenorphine long-acting + Scopolamine Major
- Buprenorphine subdermal implant + Scopolamine Major
- Buprenorphine transdermal + Scopolamine Major
- Clozapine + Scopolamine Major
- Fentanyl + Scopolamine Major
- Fentanyl intranasal + Scopolamine Major
- Fentanyl iontophoretic transdermal system + Scopolamine Major
- Fentanyl transdermal + Scopolamine Major
- Fentanyl transmucosal + Scopolamine Major
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- Pharmacokinetics
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Questions fréquentes
What is Scopolamine used for?
Scopolamine is a medicine in the class respiratory. It is used for Irritable bowel syndrome, Motion sickness, Nausea & vomiting.
What side effects have been reported with Scopolamine?
Drowsiness, Dry mouth, Blurred vision, Dizziness, Disorientation.
Can Scopolamine be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Covers hyoscine butylbromide (Buscopan, poorly absorbed by mouth) and hyoscine hydrobromide (patch, tablets). US patch label: no rise in birth defects in observational data; avoid in severe pre-eclampsia (seizures after injection). UK Buscopan: not recommended in pregnancy as a precaution. Breastfeeding: Safe. Hyoscine passes into milk. LactMed: a single dose is unlikely to affect breastfeeding, but long-term use may reduce milk supply or let-down; watch for poor feeding and weight gain. UK Buscopan: not recommended while breastfeeding (no data).
What does Scopolamine interact with?
MediHelp lists 143 known interactions for Scopolamine. Major: 17 · Moderate: 105 · Minor: 21. The most serious include Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant.
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