Référentiel des médicaments
Glycopyrrolate
Glycopyrrolate is a medicine in the class respiratory.
- Classe médicamenteuse: Respiratory
Dernière mise à jour Sources: US FDA label
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L'essentiel
- Classe médicamenteuse
- Respiratory
- Formes courantes
- comprimé, solution
- Dosages courants
- 1 mg/5 ml, 1.5 mg
- Interactions connues
- 80 (Majeure: 1 · Modérée: 48 · Mineure: 31)
- Noms commerciaux
- 2
- Pays et marchés
- 1
Mécanisme d'action
Competitive inhibitor of acetylcholine receptors on certain peripheral tissues, including salivary glands; indirectly reduces the rate of salivation by preventing stimulation of these receptors.
Grossesse et allaitement
- Grossesse
- Unknown Injection: very little crosses the placenta; widely used in anaesthesia, including caesarean section, without fetal heart effects. Oral and inhaled forms: no human data; no birth defects in rats or rabbits. Some UK injection labels: not recommended. Use only if clearly needed.
- Allaitement
- Safe No milk data; it is poorly absorbed by the infant (quaternary drug). Single doses (e.g. anaesthesia) and inhaled or skin use are unlikely to matter. Long-term oral use may reduce milk supply; watch the infant's weight gain.
Effets indésirables signalés
- Dry mouth
- Vomiting
- Constipation
- Flushing
- Nasal congestion
- Urinary retention
Contre-indications
- Medical conditions that preclude anticholinergic therapy (e.g., glaucoma, paralytic ileus, unstable cardiovascular status in acute hemorrhage, severe ulcerative colitis, toxic megacolon, myasthenia gravis).
- Concomitant solid oral dosage forms of potassium chloride.
Précautions particulières
- Constipation or intestinal pseudo-obstruction: assess for constipation, particularly within 4-5 days of initial dosing or after a dose increase.
- Diarrhea may signal incomplete mechanical intestinal obstruction; if suspected, discontinue and evaluate.
- Heat prostration can occur in high ambient temperature; avoid hot environments.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (80)
- Glycopyrrolate + Potassium chloride Major
- Amitriptyline + Glycopyrrolate Moderate
- Atropine + Glycopyrrolate Moderate
- Bethanechol + Glycopyrrolate Moderate
- Chlorpromazine + Glycopyrrolate Moderate
- Clomipramine + Glycopyrrolate Moderate
- Clozapine + Glycopyrrolate Moderate
- Cyclizine + Glycopyrrolate Moderate
- Cyclobenzaprine + Glycopyrrolate Moderate
- Darifenacin + Glycopyrrolate Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
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- Patient counselling points
- Food interactions
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Questions fréquentes
What is Glycopyrrolate used for?
Glycopyrrolate is a medicine in the class respiratory.
What side effects have been reported with Glycopyrrolate?
Dry mouth, Vomiting, Constipation, Flushing, Nasal congestion, Urinary retention.
Can Glycopyrrolate be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Injection: very little crosses the placenta; widely used in anaesthesia, including caesarean section, without fetal heart effects. Oral and inhaled forms: no human data; no birth defects in rats or rabbits. Some UK injection labels: not recommended. Use only if clearly needed. Breastfeeding: Safe. No milk data; it is poorly absorbed by the infant (quaternary drug). Single doses (e.g. anaesthesia) and inhaled or skin use are unlikely to matter. Long-term oral use may reduce milk supply; watch the infant's weight gain.
What does Glycopyrrolate interact with?
MediHelp lists 80 known interactions for Glycopyrrolate. Major: 1 · Moderate: 48 · Minor: 31. The most serious include Potassium chloride, Amitriptyline, Atropine.
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