Référentiel des médicaments
Sofpironium
Sofpironium is a medicine in the class respiratory.
- Classe médicamenteuse: Respiratory
Dernière mise à jour Sources: US FDA label
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L'essentiel
- Classe médicamenteuse
- Respiratory
- Formes courantes
- gel
- Dosages courants
- 87 mg/.67 ml
- Noms commerciaux
- 1
- Pays et marchés
- 1
Mécanisme d'action
Competitive inhibitor of acetylcholine receptors on certain peripheral tissues, including sweat glands; indirectly reduces sweating by preventing receptor stimulation.
Posologie adulte habituelle (résumé de la notice)
Primary axillary hyperhidrosis: apply 1 pump actuation per underarm (total 2 pumps), topically to clean, dry skin once a day at bedtime; do not use more than once daily.
Grossesse et allaitement
- Grossesse
- Unknown Anticholinergic gel for underarm sweating. No human data; injected doses in rats and rabbits at 10 to 31 times the maximum human dose caused no significant harm. Little is expected to reach the fetus from skin use. Use only if needed; sweating can be managed without drugs.
- Allaitement
- Unknown No human milk data; it passed into rat milk after injection. US label: weigh benefits. No LactMed record; LactMed's related glycopyrrolate record: quaternary drugs are unlikely to reach the infant, especially from skin use. Keep the infant off treated skin.
Effets indésirables signalés
- Dry mouth
- Blurred vision
- Mydriasis
- Application site pain
- Application site erythema
- Application site dermatitis
Contre-indications
- Medical conditions that can be exacerbated by anticholinergic effect (e.g., glaucoma, paralytic ileus, unstable cardiovascular status in acute hemorrhage, severe ulcerative colitis, toxic megacolon complicating ulcerative colitis, myasthenia gravis, Sjögren's syndrome).
Précautions particulières
- Urinary retention: use with caution in patients with history or presence of urinary retention; discontinue immediately and consult a provider if signs develop.
- Heat illness (hyperpyrexia, heat stroke) can occur from decreased sweating; avoid use if not sweating in hot environments.
- Transient blurred vision may occur; discontinue and avoid driving or operating machinery until resolved.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
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Questions fréquentes
What is Sofpironium used for?
Sofpironium is a medicine in the class respiratory.
What side effects have been reported with Sofpironium?
Dry mouth, Blurred vision, Mydriasis, Application site pain, Application site erythema, Application site dermatitis.
Can Sofpironium be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Anticholinergic gel for underarm sweating. No human data; injected doses in rats and rabbits at 10 to 31 times the maximum human dose caused no significant harm. Little is expected to reach the fetus from skin use. Use only if needed; sweating can be managed without drugs. Breastfeeding: Unknown. No human milk data; it passed into rat milk after injection. US label: weigh benefits. No LactMed record; LactMed's related glycopyrrolate record: quaternary drugs are unlikely to reach the infant, especially from skin use. Keep the infant off treated skin.
What does Sofpironium interact with?
MediHelp does not list a checked interaction for Sofpironium yet. Always tell your pharmacist about every medicine you take.
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