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Interactions médicamenteuses

Amitriptyline + Trihexyphenidyl

Gravité: Modérée

Amitriptyline and Trihexyphenidyl: moderate interaction.

Dernière mise à jour

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Résumé

Both drugs have strong antimuscarinic activity, so combined use can cause dry mouth, constipation, urinary retention, blurred vision, confusion and tachycardia. Older patients and those with glaucoma or prostatic enlargement are especially vulnerable.

Ce que signifie cette interaction, en termes simples

Amitriptyline and Trihexyphenidyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Amitriptyline belongs to Central Nervous System; Trihexyphenidyl belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Additive muscarinic receptor blockade.

Conduite à tenir

Monitor for anticholinergic toxicity, particularly confusion and urinary retention, and use the lowest effective doses. Consider an alternative antidepressant in elderly patients.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amitriptyline with Trihexyphenidyl?

MediHelp rates the interaction as moderate. Amitriptyline and Trihexyphenidyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have strong antimuscarinic activity, so combined use can cause dry mouth, constipation, urinary retention, blurred vision, confusion and tachycardia. Older patients and those with glaucoma or prostatic enlargement are especially vulnerable.

How serious is the interaction between Amitriptyline and Trihexyphenidyl?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, particularly confusion and urinary retention, and use the lowest effective doses. Consider an alternative antidepressant in elderly patients.

What other medicines interact with Amitriptyline?

MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.

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