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Interactions médicamenteuses

Adefovir + Pentamidine

Gravité: Majeure

Adefovir and Pentamidine: major interaction.

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Résumé

Systemic pentamidine is nephrotoxic and can cause electrolyte disturbance, and adefovir also injures the proximal tubule. Combined use raises the risk of renal impairment.

Ce que signifie cette interaction, en termes simples

Adefovir and Pentamidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Adefovir belongs to Anti Virals; Pentamidine belongs to Anti Parasitic.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive nephrotoxicity affecting renal tubular function.

Conduite à tenir

Avoid concurrent use when alternatives exist; otherwise monitor creatinine, electrolytes and phosphate frequently and adjust adefovir dosing to renal function.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Adefovir with Pentamidine?

MediHelp rates the interaction as major. Adefovir and Pentamidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Systemic pentamidine is nephrotoxic and can cause electrolyte disturbance, and adefovir also injures the proximal tubule. Combined use raises the risk of renal impairment.

How serious is the interaction between Adefovir and Pentamidine?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use when alternatives exist; otherwise monitor creatinine, electrolytes and phosphate frequently and adjust adefovir dosing to renal function.

What other medicines interact with Adefovir?

MediHelp also lists interactions of Adefovir with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Amikacin, Amphotericin b. The full list is on the Adefovir page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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