Interactions médicamenteuses
Adenovirus types 4 and 7 live + Topotecan
Gravité: Contre-indiquée
Adenovirus types 4 and 7 live and Topotecan: contraindicated interaction.
Dernière mise à jour
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Résumé
Topotecan causes myelosuppression and immunosuppression, so a live oral adenovirus vaccine may replicate excessively and cause infection. The vaccine response may also be inadequate.
Ce que signifie cette interaction, en termes simples
Adenovirus types 4 and 7 live and Topotecan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Cytotoxic immunosuppression impairs control of live attenuated virus replication and blunts vaccine-induced immunity.
Conduite à tenir
Do not give live vaccines during chemotherapy. Defer vaccination until immune recovery, typically at least 3 months after stopping treatment, and consider non-live alternatives.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Topotecan
- Amiodarone + Topotecan Majeure
- Cisplatin + Topotecan Majeure
- Cobicistat + Topotecan Majeure
- Cyclosporine + Topotecan Majeure
- Cyclosporin + Topotecan Majeure
- Darunavir + Topotecan Majeure
Questions fréquentes
Can I take Adenovirus types 4 and 7 live with Topotecan?
MediHelp rates the interaction as contraindicated. Adenovirus types 4 and 7 live and Topotecan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Topotecan causes myelosuppression and immunosuppression, so a live oral adenovirus vaccine may replicate excessively and cause infection. The vaccine response may also be inadequate.
How serious is the interaction between Adenovirus types 4 and 7 live and Topotecan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give live vaccines during chemotherapy. Defer vaccination until immune recovery, typically at least 3 months after stopping treatment, and consider non-live alternatives.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Amiodarone, Cisplatin, Cobicistat. The full list is on the Topotecan page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
