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Interactions médicamenteuses

Amiodarone + Topotecan

Gravité: Majeure

Amiodarone and Topotecan: major interaction.

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Résumé

Amiodarone inhibits P-glycoprotein and may increase topotecan exposure, especially oral topotecan. This could worsen myelosuppression and gastrointestinal toxicity.

Ce que signifie cette interaction, en termes simples

Amiodarone and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Amiodarone belongs to Cardiovascular; Topotecan belongs to Oncology.

Niveau de preuve: Moderate

Pourquoi elle survient

Amiodarone inhibits P-gp and BCRP-mediated efflux of topotecan, raising its absorption and systemic exposure.

Conduite à tenir

Avoid with oral topotecan. With IV topotecan, monitor blood counts closely and reduce dose for toxicity.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amiodarone with Topotecan?

MediHelp rates the interaction as major. Amiodarone and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone inhibits P-glycoprotein and may increase topotecan exposure, especially oral topotecan. This could worsen myelosuppression and gastrointestinal toxicity.

How serious is the interaction between Amiodarone and Topotecan?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid with oral topotecan. With IV topotecan, monitor blood counts closely and reduce dose for toxicity.

What other medicines interact with Amiodarone?

MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.

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