Interactions médicamenteuses
Cisplatin + Topotecan
Gravité: Majeure
Cisplatin and Topotecan: major interaction.
Dernière mise à jour
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Résumé
Cisplatin and topotecan both suppress bone marrow, and together they produce more severe neutropenia and thrombocytopenia than either drug alone. Myelosuppression can be dose-limiting and may lead to infection or bleeding.
Ce que signifie cette interaction, en termes simples
Cisplatin and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cisplatin belongs to Oncology; Topotecan belongs to Oncology.
Pourquoi elle survient
Additive pharmacodynamic myelosuppression, with possible sequence-dependent enhancement of toxicity.
Conduite à tenir
Monitor complete blood counts frequently and reduce topotecan dose or delay cycles for severe cytopenias. Follow established regimen sequencing and use growth factor support when indicated.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Cisplatin
- Cidofovir + Cisplatin Contre-indiquée
- Adefovir + Cisplatin Majeure
- Adenovirus types 4 and 7 live + Cisplatin Majeure
- Amikacin + Cisplatin Majeure
- Amphotericin b deoxycholate + Cisplatin Majeure
- Amphotericin b + Cisplatin Majeure
Autres interactions de Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contre-indiquée
- Amiodarone + Topotecan Majeure
- Cobicistat + Topotecan Majeure
- Cyclosporine + Topotecan Majeure
- Cyclosporin + Topotecan Majeure
- Darunavir + Topotecan Majeure
Questions fréquentes
Can I take Cisplatin with Topotecan?
MediHelp rates the interaction as major. Cisplatin and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cisplatin and topotecan both suppress bone marrow, and together they produce more severe neutropenia and thrombocytopenia than either drug alone. Myelosuppression can be dose-limiting and may lead to infection or bleeding.
How serious is the interaction between Cisplatin and Topotecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and reduce topotecan dose or delay cycles for severe cytopenias. Follow established regimen sequencing and use growth factor support when indicated.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
