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Interactions médicamenteuses

Cyclosporin + Topotecan

Gravité: Majeure

Cyclosporin and Topotecan: major interaction.

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Résumé

Cyclosporine raises topotecan exposure, particularly with oral topotecan, which may intensify myelosuppression and gastrointestinal toxicity. Both transporters involved in topotecan efflux are inhibited by cyclosporine.

Ce que signifie cette interaction, en termes simples

Cyclosporin and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Cyclosporin belongs to Miscellaneous; Topotecan belongs to Oncology.

Niveau de preuve: Moderate

Pourquoi elle survient

Cyclosporine inhibits P-glycoprotein and BCRP efflux of topotecan, increasing its absorption and reducing clearance.

Conduite à tenir

Avoid concomitant use, especially with oral topotecan; if unavoidable, monitor blood counts frequently and consider dose reduction.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cyclosporin with Topotecan?

MediHelp rates the interaction as major. Cyclosporin and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine raises topotecan exposure, particularly with oral topotecan, which may intensify myelosuppression and gastrointestinal toxicity. Both transporters involved in topotecan efflux are inhibited by cyclosporine.

How serious is the interaction between Cyclosporin and Topotecan?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use, especially with oral topotecan; if unavoidable, monitor blood counts frequently and consider dose reduction.

What other medicines interact with Cyclosporin?

MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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