Interactions médicamenteuses
Cobicistat + Topotecan
Gravité: Majeure
Cobicistat and Topotecan: major interaction.
Dernière mise à jour
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Résumé
Cobicistat inhibits P-glycoprotein and BCRP, both of which transport topotecan. Increased topotecan exposure may worsen neutropenia and other toxicities.
Ce que signifie cette interaction, en termes simples
Cobicistat and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cobicistat belongs to Miscellaneous; Topotecan belongs to Oncology.
Pourquoi elle survient
Cobicistat inhibits P-gp and BCRP efflux of topotecan, increasing its absorption and reducing elimination.
Conduite à tenir
Avoid with oral topotecan. With IV topotecan, monitor blood counts closely and consider dose reduction.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contre-indiquée
- Amiodarone + Topotecan Majeure
- Cisplatin + Topotecan Majeure
- Cyclosporine + Topotecan Majeure
- Cyclosporin + Topotecan Majeure
- Darunavir + Topotecan Majeure
Autres interactions de Cobicistat
- Alfuzosin + Cobicistat Contre-indiquée
- Apalutamide + Cobicistat Contre-indiquée
- Cobicistat + Colchicine Contre-indiquée
- Cobicistat + Dronedarone Contre-indiquée
- Cobicistat + Eletriptan Contre-indiquée
- Cobicistat + Eplerenone Contre-indiquée
Questions fréquentes
Can I take Cobicistat with Topotecan?
MediHelp rates the interaction as major. Cobicistat and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cobicistat inhibits P-glycoprotein and BCRP, both of which transport topotecan. Increased topotecan exposure may worsen neutropenia and other toxicities.
How serious is the interaction between Cobicistat and Topotecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid with oral topotecan. With IV topotecan, monitor blood counts closely and consider dose reduction.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Adenovirus types 4 and 7 live, Amiodarone, Cisplatin. The full list is on the Topotecan page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
