Interactions médicamenteuses
Alfentanil + Cimetidine
Gravité: Majeure
Alfentanil and Cimetidine: major interaction.
Dernière mise à jour
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Résumé
Cimetidine inhibits hepatic CYP3A4 and reduces alfentanil clearance, resulting in higher and prolonged opioid effect. This can cause deeper or longer respiratory depression and sedation.
Ce que signifie cette interaction, en termes simples
Alfentanil and Cimetidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Cimetidine inhibits CYP3A4-mediated metabolism of alfentanil.
Conduite à tenir
Reduce the alfentanil dose and titrate to effect, with monitoring of respiratory rate and sedation for longer than usual. Consider an H2 blocker without CYP inhibition, such as famotidine.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Cimetidine
- Cimetidine + Dofetilide Contre-indiquée
- Cimetidine + Fezolinetant Contre-indiquée
- Atazanavir + Cimetidine Majeure
- Carmustine + Cimetidine Majeure
- Cimetidine + Citalopram Majeure
- Cimetidine + Clozapine Majeure
Questions fréquentes
Can I take Alfentanil with Cimetidine?
MediHelp rates the interaction as major. Alfentanil and Cimetidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cimetidine inhibits hepatic CYP3A4 and reduces alfentanil clearance, resulting in higher and prolonged opioid effect. This can cause deeper or longer respiratory depression and sedation.
How serious is the interaction between Alfentanil and Cimetidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the alfentanil dose and titrate to effect, with monitoring of respiratory rate and sedation for longer than usual. Consider an H2 blocker without CYP inhibition, such as famotidine.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Atazanavir. The full list is on the Cimetidine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
