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Interactions médicamenteuses

Atazanavir + Cimetidine

Gravité: Majeure

Atazanavir and Cimetidine: major interaction.

Dernière mise à jour

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Résumé

Atazanavir solubility falls as gastric pH rises, so H2 antagonists such as cimetidine can substantially lower its levels. This risks virologic failure and resistance.

Ce que signifie cette interaction, en termes simples

Atazanavir and Cimetidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Atazanavir belongs to Anti Virals; Cimetidine belongs to Gastrointestinal Tract.

Niveau de preuve: High

Pourquoi elle survient

Increased gastric pH reduces atazanavir dissolution and absorption.

Conduite à tenir

Give atazanavir at least 2 hours before or 10 hours after the H2 antagonist and keep within labeled maximum H2 antagonist doses. In treatment-experienced patients use atazanavir with ritonavir per labeling.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Atazanavir with Cimetidine?

MediHelp rates the interaction as major. Atazanavir and Cimetidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir solubility falls as gastric pH rises, so H2 antagonists such as cimetidine can substantially lower its levels. This risks virologic failure and resistance.

How serious is the interaction between Atazanavir and Cimetidine?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give atazanavir at least 2 hours before or 10 hours after the H2 antagonist and keep within labeled maximum H2 antagonist doses. In treatment-experienced patients use atazanavir with ritonavir per labeling.

What other medicines interact with Cimetidine?

MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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