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Interactions médicamenteuses

Cimetidine + Dofetilide

Gravité: Contre-indiquée

Cimetidine and Dofetilide: contraindicated interaction.

Dernière mise à jour Sources: US FDA label

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Résumé

Cimetidine increases dofetilide plasma concentrations, with greater effect at higher cimetidine doses, and raises the risk of QT prolongation and torsades de pointes. Dofetilide labeling contraindicates concomitant cimetidine. Patients with renal impairment are especially vulnerable.

Ce que signifie cette interaction, en termes simples

Cimetidine and Dofetilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Cimetidine belongs to Gastrointestinal Tract; Dofetilide belongs to Cardiovascular.

Niveau de preuve: High

Pourquoi elle survient

Cimetidine inhibits renal tubular cationic secretion (OCT2/MATE) and possibly CYP3A4, reducing dofetilide renal clearance and increasing exposure.

Conduite à tenir

Do not co-administer. Use an alternative acid suppressant such as a proton pump inhibitor, or famotidine, which is not known to share this effect.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Références

Questions fréquentes

Can I take Cimetidine with Dofetilide?

MediHelp rates the interaction as contraindicated. Cimetidine and Dofetilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cimetidine increases dofetilide plasma concentrations, with greater effect at higher cimetidine doses, and raises the risk of QT prolongation and torsades de pointes. Dofetilide labeling contraindicates concomitant cimetidine. Patients with renal impairment are especially vulnerable.

How serious is the interaction between Cimetidine and Dofetilide?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Use an alternative acid suppressant such as a proton pump inhibitor, or famotidine, which is not known to share this effect.

What other medicines interact with Dofetilide?

MediHelp also lists interactions of Dofetilide with, for example, Amiodarone, Amisulpride, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Dofetilide page.

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