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Interactions médicamenteuses

Cimetidine + Fezolinetant

Gravité: Contre-indiquée

Cimetidine and Fezolinetant: contraindicated interaction.

Dernière mise à jour

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Résumé

Cimetidine inhibits CYP1A2 and can increase fezolinetant exposure, raising the risk of adverse effects including liver enzyme elevation. Fezolinetant labeling contraindicates concomitant CYP1A2 inhibitors.

Ce que signifie cette interaction, en termes simples

Cimetidine and Fezolinetant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Cimetidine belongs to Gastrointestinal Tract; Fezolinetant belongs to Endocrine.

Niveau de preuve: Moderate

Pourquoi elle survient

Inhibition of CYP1A2-mediated metabolism of fezolinetant increases its plasma concentrations.

Conduite à tenir

Do not combine; use famotidine or another non-CYP1A2-inhibiting acid suppressant. Monitor liver tests if exposure occurs.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cimetidine with Fezolinetant?

MediHelp rates the interaction as contraindicated. Cimetidine and Fezolinetant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cimetidine inhibits CYP1A2 and can increase fezolinetant exposure, raising the risk of adverse effects including liver enzyme elevation. Fezolinetant labeling contraindicates concomitant CYP1A2 inhibitors.

How serious is the interaction between Cimetidine and Fezolinetant?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use famotidine or another non-CYP1A2-inhibiting acid suppressant. Monitor liver tests if exposure occurs.

What other medicines interact with Cimetidine?

MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Alfentanil, Atazanavir. The full list is on the Cimetidine page.

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