Interactions médicamenteuses
Carmustine + Cimetidine
Gravité: Majeure
Carmustine and Cimetidine: major interaction.
Dernière mise à jour
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Résumé
Cimetidine has been reported to increase carmustine-related bone marrow suppression. This may produce deeper or more prolonged leukopenia and thrombocytopenia.
Ce que signifie cette interaction, en termes simples
Carmustine and Cimetidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carmustine belongs to Oncology; Cimetidine belongs to Gastrointestinal Tract.
Pourquoi elle survient
Cimetidine may reduce hepatic metabolism of carmustine and possibly adds to marrow suppression; the mechanism is not fully established.
Conduite à tenir
Avoid the combination where possible and use famotidine or another acid suppressant instead. If given together, monitor complete blood counts closely.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Cimetidine
- Cimetidine + Dofetilide Contre-indiquée
- Cimetidine + Fezolinetant Contre-indiquée
- Alfentanil + Cimetidine Majeure
- Atazanavir + Cimetidine Majeure
- Cimetidine + Citalopram Majeure
- Cimetidine + Clozapine Majeure
Autres interactions de Carmustine
- Carmustine + Pentostatin Contre-indiquée
- Carmustine + Chlorambucil Majeure
- Carmustine + Cyclophosphamide Majeure
- Carmustine + Dacarbazine Majeure
- Carmustine + Fingolimod Majeure
- Carmustine + Lomustine Majeure
Questions fréquentes
Can I take Carmustine with Cimetidine?
MediHelp rates the interaction as major. Carmustine and Cimetidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cimetidine has been reported to increase carmustine-related bone marrow suppression. This may produce deeper or more prolonged leukopenia and thrombocytopenia.
How serious is the interaction between Carmustine and Cimetidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use famotidine or another acid suppressant instead. If given together, monitor complete blood counts closely.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
