Interactions médicamenteuses
Glyburide-metformin + Trilaciclib
Gravité: Majeure
Glyburide-metformin and Trilaciclib: major interaction.
Dernière mise à jour
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Résumé
Trilaciclib inhibits OCT2, MATE1 and MATE2-K, so metformin concentrations are expected to increase rather than decrease. This may raise the risk of lactic acidosis, particularly with renal impairment.
Ce que signifie cette interaction, en termes simples
Glyburide-metformin and Trilaciclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Glyburide-metformin belongs to Endocrine; Trilaciclib belongs to Oncology.
Pourquoi elle survient
Trilaciclib inhibits OCT2 and MATE transporters, reducing renal clearance of metformin.
Conduite à tenir
Avoid metformin on days of trilaciclib where possible, or monitor renal function and lactate-related symptoms closely. Consider a metformin dose reduction.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Glyburide-metformin
Autres interactions de Trilaciclib
Questions fréquentes
Can I take Glyburide-metformin with Trilaciclib?
MediHelp rates the interaction as major. Glyburide-metformin and Trilaciclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trilaciclib inhibits OCT2, MATE1 and MATE2-K, so metformin concentrations are expected to increase rather than decrease. This may raise the risk of lactic acidosis, particularly with renal impairment.
How serious is the interaction between Glyburide-metformin and Trilaciclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid metformin on days of trilaciclib where possible, or monitor renal function and lactate-related symptoms closely. Consider a metformin dose reduction.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
