Interactions médicamenteuses
Amifampridine + Benzathine penicillin g
Gravité: Mineure
Amifampridine and Benzathine penicillin g: minor interaction.
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Résumé
Amifampridine carries a dose-related risk of seizures. Penicillins can lower the seizure threshold, mainly at high doses or with renal impairment, so the combined risk may be higher. Intramuscular depot benzathine penicillin gives low peak levels, so the practical risk is small.
Ce que signifie cette interaction, en termes simples
Amifampridine and Benzathine penicillin g have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amifampridine belongs to Central Nervous System; Benzathine penicillin g belongs to Anti Bacterial.
Pourquoi elle survient
Additive pharmacodynamic lowering of seizure threshold (amifampridine potassium channel blockade plus penicillin GABA-A antagonism).
Conduite à tenir
No routine change is needed. Monitor for seizure activity, particularly in patients with renal impairment, a seizure history, or when high-dose penicillin is used.
Questions à poser à votre pharmacien
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Autres interactions de Benzathine penicillin g
- Benzathine penicillin g + Cholera vaccine Modérée
- Benzathine penicillin g + Microbiota Modérée
- Benzathine penicillin g + Omadacycline Modérée
- Benzathine penicillin g + Sodium picosulfate / magnesium oxide / anhydrous citric acid Modérée
- Benzathine penicillin g + Vadadustat Modérée
- Baricitinib + Benzathine penicillin g Mineure
Autres interactions de Amifampridine
- Amifampridine + Bupropion-naltrexone Majeure
- Amantadine + Amifampridine Modérée
- Amifampridine + Amitriptyline Modérée
- Amifampridine + Baclofen Modérée
- Amifampridine + Bethanechol Modérée
- Amifampridine + Bromocriptine Modérée
Questions fréquentes
Can I take Amifampridine with Benzathine penicillin g?
MediHelp rates the interaction as minor. Amifampridine and Benzathine penicillin g have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amifampridine carries a dose-related risk of seizures. Penicillins can lower the seizure threshold, mainly at high doses or with renal impairment, so the combined risk may be higher. Intramuscular depot benzathine penicillin gives low peak levels, so the practical risk is small.
How serious is the interaction between Amifampridine and Benzathine penicillin g?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor for seizure activity, particularly in patients with renal impairment, a seizure history, or when high-dose penicillin is used.
What other medicines interact with Benzathine penicillin g?
MediHelp also lists interactions of Benzathine penicillin g with, for example, Cholera vaccine, Microbiota, Omadacycline. The full list is on the Benzathine penicillin g page.
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