Interactions médicamenteuses
Baricitinib + Benzathine penicillin g
Gravité: Mineure
Baricitinib and Benzathine penicillin g: minor interaction.
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Résumé
Penicillins can inhibit OAT3, a transporter involved in baricitinib renal elimination, so baricitinib exposure may rise. Labeling advises against strong OAT3 inhibitors such as probenecid, but penicillin G is a much weaker inhibitor and benzathine penicillin gives low sustained levels, so the effect is likely small.
Ce que signifie cette interaction, en termes simples
Baricitinib and Benzathine penicillin g have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Baricitinib belongs to Musculoskeletal; Benzathine penicillin g belongs to Anti Bacterial.
Pourquoi elle survient
Possible weak OAT3 inhibition reducing renal tubular secretion of baricitinib.
Conduite à tenir
No dose change is generally needed; monitor for baricitinib adverse effects such as infection and cytopenias as usual.
Questions à poser à votre pharmacien
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Autres interactions de Benzathine penicillin g
- Benzathine penicillin g + Cholera vaccine Modérée
- Benzathine penicillin g + Microbiota Modérée
- Benzathine penicillin g + Omadacycline Modérée
- Benzathine penicillin g + Sodium picosulfate / magnesium oxide / anhydrous citric acid Modérée
- Benzathine penicillin g + Vadadustat Modérée
- Amifampridine + Benzathine penicillin g Mineure
Autres interactions de Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contre-indiquée
- Baricitinib + Bcg vaccine live Contre-indiquée
- Baricitinib + Tofacitinib Contre-indiquée
- Baricitinib + Upadacitinib Contre-indiquée
- Abatacept + Baricitinib Majeure
- Adalimumab + Baricitinib Majeure
Questions fréquentes
Can I take Baricitinib with Benzathine penicillin g?
MediHelp rates the interaction as minor. Baricitinib and Benzathine penicillin g have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Penicillins can inhibit OAT3, a transporter involved in baricitinib renal elimination, so baricitinib exposure may rise. Labeling advises against strong OAT3 inhibitors such as probenecid, but penicillin G is a much weaker inhibitor and benzathine penicillin gives low sustained levels, so the effect is likely small.
How serious is the interaction between Baricitinib and Benzathine penicillin g?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor for baricitinib adverse effects such as infection and cytopenias as usual.
What other medicines interact with Benzathine penicillin g?
MediHelp also lists interactions of Benzathine penicillin g with, for example, Cholera vaccine, Microbiota, Omadacycline. The full list is on the Benzathine penicillin g page.
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