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Interactions médicamenteuses

Amikacin + Cefaclor

Gravité: Mineure

Amikacin and Cefaclor: minor interaction.

Dernière mise à jour

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Résumé

Cefaclor given with amikacin may add to the risk of kidney injury, particularly in patients with renal impairment or volume depletion. Amikacin is the principal nephrotoxic and ototoxic drug, and reduced renal function increases its exposure. Oral cefaclor is only weakly nephrotoxic.

Ce que signifie cette interaction, en termes simples

Amikacin and Cefaclor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.

Amikacin belongs to Anti Bacterial; Cefaclor belongs to Anti Bacterial.

Niveau de preuve: Low

Pourquoi elle survient

Possible additive nephrotoxic potential; evidence for cefaclor is weak.

Conduite à tenir

Monitor serum creatinine and amikacin levels during therapy. Adjust the amikacin dose for renal function.

Questions à poser à votre pharmacien

  • Is there anything I should notice while taking both?
  • Do I need to tell my doctor at the next visit?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amikacin with Cefaclor?

MediHelp rates the interaction as minor. Amikacin and Cefaclor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cefaclor given with amikacin may add to the risk of kidney injury, particularly in patients with renal impairment or volume depletion. Amikacin is the principal nephrotoxic and ototoxic drug, and reduced renal function increases its exposure. Oral cefaclor is only weakly nephrotoxic.

How serious is the interaction between Amikacin and Cefaclor?

MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and amikacin levels during therapy. Adjust the amikacin dose for renal function.

What other medicines interact with Cefaclor?

MediHelp also lists interactions of Cefaclor with, for example, Bcg vaccine live, Cholera vaccine, Kanamycin. The full list is on the Cefaclor page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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