Interactions médicamenteuses
Amikacin + Rocuronium
Gravité: Majeure
Amikacin and Rocuronium: major interaction.
Dernière mise à jour
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Résumé
Amikacin can intensify and prolong neuromuscular blockade from rocuronium. This may lead to delayed recovery, respiratory depression or apnea, especially in renal impairment.
Ce que signifie cette interaction, en termes simples
Amikacin and Rocuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amikacin belongs to Anti Bacterial; Rocuronium belongs to Musculoskeletal.
Pourquoi elle survient
Aminoglycosides inhibit presynaptic acetylcholine release and reduce postsynaptic sensitivity, adding to competitive nicotinic blockade.
Conduite à tenir
Monitor with train-of-four and reduce rocuronium dosing as needed. Keep ventilatory support available until full recovery is confirmed.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Rocuronium
- Bacitracin-neomycin-polymyxin + Rocuronium Majeure
- Capreomycin + Rocuronium Majeure
- Clindamycin + Rocuronium Majeure
- Colistin + Rocuronium Majeure
- Dexamethasone-tobramycin + Rocuronium Majeure
- Gentamicin + Rocuronium Majeure
Autres interactions de Amikacin
- Amikacin + Cidofovir Contre-indiquée
- Adefovir + Amikacin Majeure
- Amikacin + Amphotericin b Majeure
- Amikacin + Amphotericin b deoxycholate Majeure
- Amikacin + Atracurium Majeure
- Amikacin + Bacitracin Majeure
Questions fréquentes
Can I take Amikacin with Rocuronium?
MediHelp rates the interaction as major. Amikacin and Rocuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amikacin can intensify and prolong neuromuscular blockade from rocuronium. This may lead to delayed recovery, respiratory depression or apnea, especially in renal impairment.
How serious is the interaction between Amikacin and Rocuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor with train-of-four and reduce rocuronium dosing as needed. Keep ventilatory support available until full recovery is confirmed.
What other medicines interact with Rocuronium?
MediHelp also lists interactions of Rocuronium with, for example, Bacitracin-neomycin-polymyxin, Capreomycin, Clindamycin. The full list is on the Rocuronium page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
