Interactions médicamenteuses
Gentamicin + Rocuronium
Gravité: Majeure
Gentamicin and Rocuronium: major interaction.
Dernière mise à jour
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Résumé
Gentamicin can intensify and prolong neuromuscular blockade from rocuronium. This can lead to delayed recovery, respiratory depression or apnea, particularly with high doses or renal impairment.
Ce que signifie cette interaction, en termes simples
Gentamicin and Rocuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gentamicin belongs to Anti Bacterial; Rocuronium belongs to Musculoskeletal.
Pourquoi elle survient
Aminoglycosides inhibit presynaptic acetylcholine release and reduce postsynaptic sensitivity, adding to competitive nicotinic blockade.
Conduite à tenir
Use train-of-four monitoring and reduce rocuronium doses as required. Ensure ventilatory support until full neuromuscular recovery.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Rocuronium
- Amikacin + Rocuronium Majeure
- Bacitracin-neomycin-polymyxin + Rocuronium Majeure
- Capreomycin + Rocuronium Majeure
- Clindamycin + Rocuronium Majeure
- Colistin + Rocuronium Majeure
- Dexamethasone-tobramycin + Rocuronium Majeure
Autres interactions de Gentamicin
- Cidofovir + Gentamicin Contre-indiquée
- Adefovir + Gentamicin Majeure
- Amikacin + Gentamicin Majeure
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Majeure
- Amphotericin b deoxycholate + Gentamicin Majeure
- Amphotericin b + Gentamicin Majeure
Questions fréquentes
Can I take Gentamicin with Rocuronium?
MediHelp rates the interaction as major. Gentamicin and Rocuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gentamicin can intensify and prolong neuromuscular blockade from rocuronium. This can lead to delayed recovery, respiratory depression or apnea, particularly with high doses or renal impairment.
How serious is the interaction between Gentamicin and Rocuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use train-of-four monitoring and reduce rocuronium doses as required. Ensure ventilatory support until full neuromuscular recovery.
What other medicines interact with Rocuronium?
MediHelp also lists interactions of Rocuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Rocuronium page.
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