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Interactions médicamenteuses

Clindamycin + Rocuronium

Gravité: Majeure

Clindamycin and Rocuronium: major interaction.

Dernière mise à jour

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Résumé

Clindamycin has intrinsic neuromuscular blocking activity and can deepen and prolong paralysis from rocuronium. Recovery of spontaneous breathing may be delayed.

Ce que signifie cette interaction, en termes simples

Clindamycin and Rocuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Clindamycin belongs to Anti Bacterial; Rocuronium belongs to Musculoskeletal.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive neuromuscular blockade through presynaptic and postsynaptic inhibition of transmission by clindamycin.

Conduite à tenir

Monitor train-of-four and titrate rocuronium to effect. Ensure full recovery of neuromuscular function before extubation.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Clindamycin with Rocuronium?

MediHelp rates the interaction as major. Clindamycin and Rocuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clindamycin has intrinsic neuromuscular blocking activity and can deepen and prolong paralysis from rocuronium. Recovery of spontaneous breathing may be delayed.

How serious is the interaction between Clindamycin and Rocuronium?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor train-of-four and titrate rocuronium to effect. Ensure full recovery of neuromuscular function before extubation.

What other medicines interact with Rocuronium?

MediHelp also lists interactions of Rocuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Rocuronium page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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