Interactions médicamenteuses
Amiodarone + Timolol
Gravité: Majeure
Amiodarone and Timolol: major interaction.
Dernière mise à jour
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Résumé
Amiodarone can cause bradycardia and AV block, and combined with timolol the risk of severe bradycardia, conduction disturbance or cardiac arrest increases. Amiodarone may also raise timolol levels through CYP2D6 inhibition, including with ophthalmic timolol.
Ce que signifie cette interaction, en termes simples
Amiodarone and Timolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Pourquoi elle survient
Additive negative chronotropic and dromotropic effects, plus CYP2D6 inhibition by amiodarone reducing timolol clearance.
Conduite à tenir
Monitor heart rate and ECG, and reduce the timolol dose or avoid the combination in patients with conduction disease or low baseline heart rate.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Timolol
- Acebutolol + Timolol Majeure
- Albuterol + Timolol Majeure
- Aldesleukin + Timolol Majeure
- Amifostine + Timolol Majeure
- Arformoterol + Timolol Majeure
- Atenolol-chlorthalidone + Timolol Majeure
Autres interactions de Amiodarone
- Amiodarone + Amisulpride Contre-indiquée
- Amiodarone + Arsenic trioxide Contre-indiquée
- Amiodarone + Dofetilide Contre-indiquée
- Amiodarone + Dronedarone Contre-indiquée
- Amiodarone + Droperidol Contre-indiquée
- Amiodarone + Eliglustat Contre-indiquée
Questions fréquentes
Can I take Amiodarone with Timolol?
MediHelp rates the interaction as major. Amiodarone and Timolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone can cause bradycardia and AV block, and combined with timolol the risk of severe bradycardia, conduction disturbance or cardiac arrest increases. Amiodarone may also raise timolol levels through CYP2D6 inhibition, including with ophthalmic timolol.
How serious is the interaction between Amiodarone and Timolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG, and reduce the timolol dose or avoid the combination in patients with conduction disease or low baseline heart rate.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
