Interactions médicamenteuses
Amitriptyline + Dicyclomine
Gravité: Modérée
Amitriptyline and Dicyclomine: moderate interaction.
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Résumé
Both drugs have antimuscarinic activity, so combined use increases the risk of dry mouth, constipation, urinary retention, blurred vision and confusion. Older adults and those with glaucoma, prostatic enlargement or ileus are at particular risk.
Ce que signifie cette interaction, en termes simples
Amitriptyline and Dicyclomine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Dicyclomine belongs to Respiratory.
Pourquoi elle survient
Additive muscarinic receptor blockade.
Conduite à tenir
Monitor for anticholinergic effects, and consider a lower dose or an alternative with less antimuscarinic activity in older patients. Avoid in patients with urinary retention, narrow-angle glaucoma or ileus.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Dicyclomine
- Clozapine + Dicyclomine Majeure
- Dicyclomine + Henbane Majeure
- Dicyclomine + Imipramine Majeure
- Dicyclomine + Pramlintide Majeure
- Abobotulinumtoxina + Dicyclomine Modérée
- Aclidinium + Dicyclomine Modérée
Autres interactions de Amitriptyline
- Amitriptyline + Isocarboxazid Contre-indiquée
- Amitriptyline + Methylene blue Contre-indiquée
- Amitriptyline + Phenelzine Contre-indiquée
- Amitriptyline + Pimozide Contre-indiquée
- Amitriptyline + Procarbazine Contre-indiquée
- Amitriptyline + Safinamide Contre-indiquée
Questions fréquentes
Can I take Amitriptyline with Dicyclomine?
MediHelp rates the interaction as moderate. Amitriptyline and Dicyclomine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have antimuscarinic activity, so combined use increases the risk of dry mouth, constipation, urinary retention, blurred vision and confusion. Older adults and those with glaucoma, prostatic enlargement or ileus are at particular risk.
How serious is the interaction between Amitriptyline and Dicyclomine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects, and consider a lower dose or an alternative with less antimuscarinic activity in older patients. Avoid in patients with urinary retention, narrow-angle glaucoma or ileus.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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