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Interactions médicamenteuses

Amlodipine-benazepril + Canagliflozin

Gravité: Modérée

Amlodipine-benazepril and Canagliflozin: moderate interaction.

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Résumé

Canagliflozin does not typically raise potassium in the way potassium-sparing agents do, and it may even lower hyperkalemia risk. The more relevant concern is additive volume depletion and hypotension with benazepril, with possible effects on renal function.

Ce que signifie cette interaction, en termes simples

Amlodipine-benazepril and Canagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Amlodipine-benazepril belongs to Cardiovascular; Canagliflozin belongs to Endocrine.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive hypotensive and volume-depleting effects from osmotic diuresis plus RAAS inhibition.

Conduite à tenir

Assess volume status and monitor blood pressure, creatinine and potassium after starting canagliflozin. Reduce diuretic or antihypertensive doses if hypovolemia develops.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amlodipine-benazepril with Canagliflozin?

MediHelp rates the interaction as moderate. Amlodipine-benazepril and Canagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin does not typically raise potassium in the way potassium-sparing agents do, and it may even lower hyperkalemia risk. The more relevant concern is additive volume depletion and hypotension with benazepril, with possible effects on renal function.

How serious is the interaction between Amlodipine-benazepril and Canagliflozin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status and monitor blood pressure, creatinine and potassium after starting canagliflozin. Reduce diuretic or antihypertensive doses if hypovolemia develops.

What other medicines interact with Amlodipine-benazepril?

MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.

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