Drug interactions
Amlodipine-benazepril + Canagliflozin
Severity: Moderate
Amlodipine-benazepril and Canagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canagliflozin does not typically raise potassium in the way potassium-sparing agents do, and it may even lower hyperkalemia risk. The more relevant concern is additive volume depletion and hypotension with benazepril, with possible effects on renal function.
What this interaction means in plain words
Amlodipine-benazepril and Canagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Canagliflozin belongs to Endocrine.
Why it happens
Additive hypotensive and volume-depleting effects from osmotic diuresis plus RAAS inhibition.
What to do
Assess volume status and monitor blood pressure, creatinine and potassium after starting canagliflozin. Reduce diuretic or antihypertensive doses if hypovolemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Canagliflozin
Frequently asked questions
Can I take Amlodipine-benazepril with Canagliflozin?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Canagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin does not typically raise potassium in the way potassium-sparing agents do, and it may even lower hyperkalemia risk. The more relevant concern is additive volume depletion and hypotension with benazepril, with possible effects on renal function.
How serious is the interaction between Amlodipine-benazepril and Canagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status and monitor blood pressure, creatinine and potassium after starting canagliflozin. Reduce diuretic or antihypertensive doses if hypovolemia develops.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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