Interactions médicamenteuses
Amlodipine-perindopril + Canagliflozin
Gravité: Modérée
Amlodipine-perindopril and Canagliflozin: moderate interaction.
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Résumé
Canagliflozin is generally not strongly hyperkalemic, but it can cause volume depletion and hypotension, and combined with an ACE inhibitor may impair kidney function. Canagliflozin has been associated with small potassium rises in patients with renal impairment.
Ce que signifie cette interaction, en termes simples
Amlodipine-perindopril and Canagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Canagliflozin belongs to Endocrine.
Pourquoi elle survient
Additive effects: osmotic diuresis and volume contraction with ACE inhibitor reduction of efferent arteriolar tone may lower glomerular filtration and impair potassium excretion.
Conduite à tenir
Check volume status, blood pressure, renal function and serum potassium after starting canagliflozin; reduce diuretic doses if the patient is volume depleted.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contre-indiquée
- Amlodipine-perindopril + Protein a column Contre-indiquée
- Amlodipine-perindopril + Sacubitril / valsartan Contre-indiquée
- Amifostine + Amlodipine-perindopril Majeure
- Amiloride + Amlodipine-perindopril Majeure
- Amlodipine-perindopril + Azilsartan Majeure
Autres interactions de Canagliflozin
Questions fréquentes
Can I take Amlodipine-perindopril with Canagliflozin?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Canagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin is generally not strongly hyperkalemic, but it can cause volume depletion and hypotension, and combined with an ACE inhibitor may impair kidney function. Canagliflozin has been associated with small potassium rises in patients with renal impairment.
How serious is the interaction between Amlodipine-perindopril and Canagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check volume status, blood pressure, renal function and serum potassium after starting canagliflozin; reduce diuretic doses if the patient is volume depleted.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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