Interactions médicamenteuses
Amlodipine-perindopril + Carbidopa
Gravité: Modérée
Amlodipine-perindopril and Carbidopa: moderate interaction.
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Résumé
Carbidopa is given with levodopa, and levodopa can cause orthostatic hypotension that adds to the effects of antihypertensives. Patients on amlodipine and perindopril may have more pronounced blood pressure falls when levodopa-carbidopa is started or increased.
Ce que signifie cette interaction, en termes simples
Amlodipine-perindopril and Carbidopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Carbidopa belongs to Central Nervous System.
Pourquoi elle survient
Additive hypotension, as levodopa formed in the presence of carbidopa adds to the vasodilatory and ACE-inhibitor effects.
Conduite à tenir
Monitor standing and sitting blood pressure when starting or adjusting levodopa-carbidopa. Reduce the antihypertensive dose if symptomatic hypotension occurs.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contre-indiquée
- Amlodipine-perindopril + Protein a column Contre-indiquée
- Amlodipine-perindopril + Sacubitril / valsartan Contre-indiquée
- Amifostine + Amlodipine-perindopril Majeure
- Amiloride + Amlodipine-perindopril Majeure
- Amlodipine-perindopril + Azilsartan Majeure
Autres interactions de Carbidopa
Questions fréquentes
Can I take Amlodipine-perindopril with Carbidopa?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Carbidopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbidopa is given with levodopa, and levodopa can cause orthostatic hypotension that adds to the effects of antihypertensives. Patients on amlodipine and perindopril may have more pronounced blood pressure falls when levodopa-carbidopa is started or increased.
How serious is the interaction between Amlodipine-perindopril and Carbidopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor standing and sitting blood pressure when starting or adjusting levodopa-carbidopa. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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