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Interactions médicamenteuses

Amobarbital + Ranolazine

Gravité: Contre-indiquée

Amobarbital and Ranolazine: contraindicated interaction.

Dernière mise à jour

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Résumé

Barbiturates are CYP3A4 inducers and can substantially lower ranolazine concentrations. This may lead to loss of antianginal efficacy.

Ce que signifie cette interaction, en termes simples

Amobarbital and Ranolazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Amobarbital belongs to Central Nervous System; Ranolazine belongs to Cardiovascular.

Niveau de preuve: Moderate

Pourquoi elle survient

Induction of hepatic and intestinal CYP3A4 (and P-gp) increasing ranolazine clearance.

Conduite à tenir

Do not use together; ranolazine labeling contraindicates CYP3A inducers such as barbiturates. Choose an alternative antianginal or sedative.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amobarbital with Ranolazine?

MediHelp rates the interaction as contraindicated. Amobarbital and Ranolazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Barbiturates are CYP3A4 inducers and can substantially lower ranolazine concentrations. This may lead to loss of antianginal efficacy.

How serious is the interaction between Amobarbital and Ranolazine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; ranolazine labeling contraindicates CYP3A inducers such as barbiturates. Choose an alternative antianginal or sedative.

What other medicines interact with Ranolazine?

MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Apalutamide, Butabarbital. The full list is on the Ranolazine page.

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