Aller au contenu
MediHelp
MediHelp Référence médicamenteuse

Interactions médicamenteuses

Apalutamide + Ranolazine

Gravité: Contre-indiquée

Apalutamide and Ranolazine: contraindicated interaction.

Dernière mise à jour

Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.

Le contenu clinique de cette page n'est disponible qu'en anglais.

Résumé

Apalutamide is a strong CYP3A4 inducer and is expected to markedly reduce ranolazine exposure. Antianginal benefit may be lost.

Ce que signifie cette interaction, en termes simples

Apalutamide and Ranolazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Apalutamide belongs to Endocrine; Ranolazine belongs to Cardiovascular.

Niveau de preuve: Moderate

Pourquoi elle survient

Induction of CYP3A4 and P-gp accelerating ranolazine metabolism.

Conduite à tenir

Avoid concurrent use, as ranolazine labeling contraindicates strong CYP3A inducers. Use another antianginal during apalutamide therapy.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Réservé aux membres Pro+

Débloquer la page complète

Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Apalutamide et Ranolazine, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
Créer un compte gratuit Se connecter

Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.

Questions fréquentes

Can I take Apalutamide with Ranolazine?

MediHelp rates the interaction as contraindicated. Apalutamide and Ranolazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Apalutamide is a strong CYP3A4 inducer and is expected to markedly reduce ranolazine exposure. Antianginal benefit may be lost.

How serious is the interaction between Apalutamide and Ranolazine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use, as ranolazine labeling contraindicates strong CYP3A inducers. Use another antianginal during apalutamide therapy.

What other medicines interact with Ranolazine?

MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Butabarbital. The full list is on the Ranolazine page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

Télécharger surApp Store Disponible surGoogle Play

Parcourir de A à Z · Interactions médicamenteuses

Télécharger l'app Se connecter