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Interactions médicamenteuses

Cobicistat + Ranolazine

Gravité: Contre-indiquée

Cobicistat and Ranolazine: contraindicated interaction.

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Résumé

Cobicistat strongly inhibits CYP3A4 and markedly raises ranolazine concentrations. This increases dose-related QT prolongation and other adverse effects, and strong CYP3A inhibitors are contraindicated with ranolazine.

Ce que signifie cette interaction, en termes simples

Cobicistat and Ranolazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Cobicistat belongs to Miscellaneous; Ranolazine belongs to Cardiovascular.

Niveau de preuve: High

Pourquoi elle survient

Potent CYP3A4 inhibition by cobicistat reduces ranolazine clearance.

Conduite à tenir

Do not use together. Use an alternative antianginal for patients who need a cobicistat-boosted regimen.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cobicistat with Ranolazine?

MediHelp rates the interaction as contraindicated. Cobicistat and Ranolazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cobicistat strongly inhibits CYP3A4 and markedly raises ranolazine concentrations. This increases dose-related QT prolongation and other adverse effects, and strong CYP3A inhibitors are contraindicated with ranolazine.

How serious is the interaction between Cobicistat and Ranolazine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Use an alternative antianginal for patients who need a cobicistat-boosted regimen.

What other medicines interact with Ranolazine?

MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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