Interactions médicamenteuses
Amoxicillin-clavulanic acid + Nivolumab
Gravité: Mineure
Amoxicillin-clavulanic acid and Nivolumab: minor interaction.
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Résumé
Observational data link antibiotic exposure around the start of immune checkpoint inhibitor therapy with poorer outcomes, possibly through gut microbiome disruption. The evidence is associative and confounded by patient illness severity. The effect on any individual patient is uncertain.
Ce que signifie cette interaction, en termes simples
Amoxicillin-clavulanic acid and Nivolumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amoxicillin-clavulanic acid belongs to Anti Bacterial; Nivolumab belongs to Oncology.
Pourquoi elle survient
Proposed disruption of gut microbiota that may modulate antitumor immune response; not firmly established.
Conduite à tenir
Prescribe the antibiotic only when there is a clear infection indication and keep the course as short as clinically appropriate. Do not withhold needed antibiotics.
Questions à poser à votre pharmacien
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Autres interactions de Amoxicillin-clavulanic acid
- Amoxicillin-clavulanic acid + Methotrexate Majeure
- Amoxicillin-clavulanic acid + Pexidartinib Majeure
- Amoxicillin-clavulanic acid + Pretomanid Majeure
- Allopurinol + Amoxicillin-clavulanic acid Modérée
- Amoxicillin-clavulanic acid + Bcg vaccine live Modérée
- Amoxicillin-clavulanic acid + Chloramphenicol Modérée
Autres interactions de Nivolumab
- Nivolumab + Thalidomide Majeure
- Dexamethasone-tobramycin + Nivolumab Modérée
- Dexamethasone + Nivolumab Modérée
- Efgartigimod / hyaluronidase sc + Nivolumab Modérée
- Efgartigimod alfa + Nivolumab Modérée
- Nivolumab + Ponesimod Modérée
Questions fréquentes
Can I take Amoxicillin-clavulanic acid with Nivolumab?
MediHelp rates the interaction as minor. Amoxicillin-clavulanic acid and Nivolumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Observational data link antibiotic exposure around the start of immune checkpoint inhibitor therapy with poorer outcomes, possibly through gut microbiome disruption. The evidence is associative and confounded by patient illness severity. The effect on any individual patient is uncertain.
How serious is the interaction between Amoxicillin-clavulanic acid and Nivolumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prescribe the antibiotic only when there is a clear infection indication and keep the course as short as clinically appropriate. Do not withhold needed antibiotics.
What other medicines interact with Amoxicillin-clavulanic acid?
MediHelp also lists interactions of Amoxicillin-clavulanic acid with, for example, Methotrexate, Pexidartinib, Pretomanid. The full list is on the Amoxicillin-clavulanic acid page.
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